{"product_id":"principelle-if-medical-grade-honey-based-bio-active-wound-care-formulation-5cm-x-6cm","title":"Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10","description":"\u003cdiv style=\"background: #f8f9fa; border-left: 4px solid #0057a8; padding: 12px 16px; margin-bottom: 20px;\" id=\"ai-summary\"\u003e\n\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e Principelle IF is a sterile medical-grade honey wound dressing consisting of an acetate substrate impregnated with dark buckwheat honey supplemented with trace elements and mineral oxides, presenting antimicrobial activity via multiple simultaneous mechanisms: hydrogen peroxide generation (glucose oxidase enzyme), osmotic gradient (approximately 80% sugar content by weight), low pH, and direct phenolic compound activity against resistant organisms including MRSA. Indicated for acute and chronic wounds requiring autolytic debridement, infected or colonised wound beds, diabetic foot ulcers, sloughy wounds, and burn wounds; supplied sterile in a box of 10 dressings (5 cm x 6 cm each), classified minimum Class B under Singapore HSA GN-13 guidance, with CE marking to EU MDR 2017\/745 standards.\u003c\/div\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003ePrincipelle IF Medical Grade Honey Wound Care Formulation is a bioactive wound contact layer combining the antimicrobial and wound-healing properties of medical-grade dark buckwheat honey with trace elements and mineral oxides on an acetate carrier substrate. Medical-grade honey exerts antimicrobial effect through at least four concurrent mechanisms: glucose oxidase catalyses continuous low-level hydrogen peroxide (H2O2) generation upon contact with wound exudate; high osmolarity (approximately 80% sugar by weight) creates an osmotic gradient that draws fluid from the wound bed and desiccates bacteria; acidic pH (approximately 3.2–4.5) creates a hostile environment for bacterial metabolism; and phenolic compounds, flavonoids, and organic acids contribute direct antimicrobial activity independent of H2O2, providing efficacy even where wound catalase enzyme may neutralise peroxide activity.\u003c\/p\u003e\n\u003cp\u003eMedical-grade honey wound dressings are distinguished from food-grade honey by mandatory gamma irradiation sterilisation, validated to ISO 11137 (Sterilization of Health Care Products — Radiation), which eliminates Clostridium spores at 25 kGy without significantly reducing antibacterial potency. In vitro evidence demonstrates broad-spectrum antimicrobial coverage including methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and vancomycin-resistant enterococci (VRE). Anti-biofilm activity has been demonstrated against Pseudomonas aeruginosa biofilms, disrupting biofilm architecture through multiple simultaneous pathway pressure — a key clinical advantage in chronic wounds where biofilm is a primary barrier to healing.\u003c\/p\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBrand\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003ePrincipelle\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eHoney Type\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eDark buckwheat honey with trace elements and mineral oxides\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSubstrate\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSterile acetate mesh impregnated with honey-mineral ointment\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eDimensions\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e5 cm x 6 cm per dressing; box of 10\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eSterility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eSterile; gamma-irradiated per ISO 11137\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eRegulatory — EU\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eCE Mark; EU MDR 2017\/745; Class IIa or IIb bioactive wound dressing\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eRegulatory — Singapore\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eHSA medical device registration; minimum Class B under GN-13 Guidance; Health Products Act Cap. 122D\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eBiocompatibility\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eISO 10993 series: ISO 10993-5 cytotoxicity, ISO 10993-23 irritation testing\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eWear Time\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eUp to 7 days (low exudate); every 1–3 days (moderate-to-high exudate)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eQuality System\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003eISO 13485 medical device quality management\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eKey Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eInfected and critically colonised wounds:\u003c\/strong\u003e Broad-spectrum antimicrobial activity including MRSA, Pseudomonas aeruginosa, and VRE; indicated per WUWHS biofilm-based wound care recommendations.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChronic wound autolytic debridement:\u003c\/strong\u003e Osmotic gradient and enzymatic activity facilitate autolytic debridement of sloughy or necrotic tissue — venous leg ulcers, pressure injuries Stage 2–4, non-healing surgical wounds.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiabetic foot ulcers:\u003c\/strong\u003e Multi-mechanism antimicrobial activity addresses high biofilm burden; used within multidisciplinary diabetic foot team protocols per Singapore MOH clinical practice guidelines.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBurn wound management:\u003c\/strong\u003e Moist wound healing with anti-inflammatory properties supports re-epithelialisation in partial-thickness burns; atraumatic acetate substrate removal via saline moistening.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePost-surgical dehisced wounds:\u003c\/strong\u003e Antimicrobial environment without the cytotoxic profile of iodine- or silver-based dressings at equivalent change frequencies.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMalodorous chronic wounds:\u003c\/strong\u003e Multi-mechanism antimicrobial activity reduces bacterial load responsible for wound malodour, improving patient quality of life in community wound care settings.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What distinguishes medical-grade from food-grade honey in wound care?\u003c\/strong\u003e\u003cbr\u003eA: Medical-grade honey must be gamma-irradiated to sterility validated per ISO 11137, eliminating Clostridium botulinum spore risk in open wounds — not addressed by food-grade honey. Medical-grade honey is sourced from specific botanical origins selected for documented antibacterial potency, subject to batch-specific potency testing and ISO 13485 quality management. Food-grade honey carries infection risk and inconsistent antimicrobial potency.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Why does exudate increase after initial application?\u003c\/strong\u003e\u003cbr\u003eA: The osmotic effect of medical-grade honey typically increases exudate volume in the first 24–48 hours as fluid is drawn from surrounding tissues. This is expected physiology, not deterioration. Clinicians should apply an appropriately absorbent secondary dressing (foam or alginate pad) and advise carers accordingly. Exudate management should be reassessed at the first dressing change.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is antimicrobial resistance to honey a clinical concern?\u003c\/strong\u003e\u003cbr\u003eA: Unlike antibiotics targeting specific metabolic pathways, medical-grade honey operates through multiple simultaneous mechanisms (osmosis, pH, hydrogen peroxide, phenolic compounds). No clinically significant emergence of honey resistance has been documented in published literature, supporting its use in multi-drug resistant organism (MDRO) management.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How is Principelle IF registered and supplied in Singapore?\u003c\/strong\u003e\u003cbr\u003eA: Advanced wound dressings with bioactive antimicrobial properties are classified under the Singapore Health Products Act (Cap. 122D) as medical devices requiring HSA registration (minimum Class B, potentially Class C under GN-13 guidance). EMIS supplies Principelle IF to hospitals, polyclinics, nursing homes, and home care providers through registered distribution channels.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What is the recommended removal technique?\u003c\/strong\u003e\u003cbr\u003eA: Apply sterile 0.9% sodium chloride or Ringer's solution to moisten the dressing and loosen the honey-substrate layer. Allow 30–60 seconds before gentle peeling from wound edges inward. Dry removal risks mechanical trauma to granulation tissue. This atraumatic protocol aligns with Singapore MOH IPC guidelines for wound dressing procedures.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAvailable in Singapore from EMIS (Essential Medical International Supplies Pte Ltd), Box of 10. For institutional and B2B procurement enquiries, contact our team at emis.asia.\u003c\/em\u003e\u003c\/p\u003e\n\n\u003cscript type=\"application\/ld+json\"\u003e\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@type\": \"FAQPage\",\n  \"mainEntity\": [\n    {\n      \"@type\": \"Question\",\n      \"name\": \"What is Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 used for?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 by Principelle is a advanced wound dressing used for wound management. It is designed to support moist wound healing, manage exudate, and protect the wound bed from contamination. It is commonly used in Singapore hospitals and home care settings for chronic wounds, post-surgical wounds, and ulcers. Always follow the guidance of your wound care nurse or doctor when selecting a dressing.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"How often should Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 be changed?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 should generally be changed every 1–7 days depending on wound type and exudate. However, frequency should always be guided by your wound care nurse or clinician based on wound size, exudate level, and signs of infection. Do not leave any dressing in place if it becomes saturated, dislodged, or if the wound shows signs of infection such as increased redness, warmth, or discharge.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Is Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 available without prescription in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Yes, Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 is available for purchase from EMIS+ (emis.asia) without a prescription for general wound care use. For complex or chronic wounds, we strongly recommend consulting a wound care nurse, GP, or specialist at a Singapore hospital such as SGH, NUH, TTSH, or CGH before selecting a dressing. EMIS+ nurses can also provide product guidance — contact us at emis.asia\/pages\/contact.\"\n      }\n    },\n    {\n      \"@type\": \"Question\",\n      \"name\": \"Where can I buy Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 in Singapore?\",\n      \"acceptedAnswer\": {\n        \"@type\": \"Answer\",\n        \"text\": \"Principelle If Medical Grade Honey Based Bio Active Wound Care Formulation 5cm x 6cm Box of 10 is available from EMIS+ at emis.asia, Singapore's nurse-led medical supply store. We offer fast island-wide delivery, competitive pricing, and bulk ordering for healthcare facilities and home care users. Visit emis.asia or contact our team for assistance.\"\n      }\n    }\n  ]\n}\n\u003c\/script\u003e","brand":"Principelle","offers":[{"title":"Default Title","offer_id":42741428650062,"sku":null,"price":180.0,"currency_code":"SGD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/Principelle_IF_5cm_x_6cm_5.png?v=1753974875","url":"https:\/\/tw.emis.asia\/products\/principelle-if-medical-grade-honey-based-bio-active-wound-care-formulation-5cm-x-6cm","provider":"EMIS+","version":"1.0","type":"link"}