{"product_id":"crystal-tomato-whitening-supplements-clinically-proven-skin-brightening-for-radiant-luminous-skin","title":"Crystal Tomato Whitening Supplements: Clinically Proven Skin Brightening for Radiant, Luminous Skin","description":"\u003cdiv style=\"background: #f8f9fa; border-left: 4px solid #0057a8; padding: 12px 16px; margin-bottom: 20px;\" id=\"ai-summary\"\u003e\n\u003cstrong\u003eClinical Summary:\u003c\/strong\u003e Crystal Tomato® Whitening Supplement is an oral skin-brightening dietary supplement standardised to colourless carotenoids — phytoene and phytofluene — extracted from a proprietary non-genetically modified (non-GMO) tomato cultivar. The supplement was evaluated in a double-blind, placebo-controlled, randomised clinical trial at the National Skin Centre, Singapore, which reported a 46% reduction in modified Melasma Area and Severity Index (mMASI) scores in the active arm versus 35% on placebo over a 54-day study period, with no irritation or systemic adverse effects reported. Daily oral dosing is intended as an adjunct to topical photoprotection and dermatologist-led pigmentation management.\u003c\/div\u003e\n\u003ch2\u003eProduct Overview\u003c\/h2\u003e\n\u003cp\u003eCrystal Tomato® is a Singapore-developed oral whitening supplement built around colourless carotenoids (phytoene and phytofluene), the immediate biosynthetic precursors of the better-known coloured carotenoids lycopene and beta-carotene. The active raw material is sourced from a proprietary non-GMO tomato cultivar reported by the manufacturer to contain approximately 500-fold higher bio-accessible colourless carotenoid content than standard tomatoes. Unlike the coloured carotenoids, phytoene and phytofluene do not absorb in the visible spectrum and have absorption maxima in the UV-B\/UV-A range, providing photo-stabilising and antioxidant properties when distributed to the skin via the systemic circulation.\u003c\/p\u003e\n\u003cp\u003eMechanistically, oral phytoene\/phytofluene supplementation has been associated with reduced UV-induced erythema, attenuated melanogenesis (inhibition of tyrosinase activity in vitro) and a reduction in oxidative-stress-driven post-inflammatory hyperpigmentation. Clinical evaluation at the National Skin Centre Singapore demonstrated statistically significant reductions in mMASI scores and improvement in skin luminosity over 54 days. Crystal Tomato® is intended for use under the guidance of a dermatologist or aesthetic physician as part of an integrated regimen that includes broad-spectrum sunscreen, topical depigmenting agents and avoidance of UV exposure.\u003c\/p\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable style=\"border-collapse: collapse; width: 100%;\" cellspacing=\"0\" cellpadding=\"6\" border=\"1\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eManufacturer \/ Brand\u003c\/th\u003e\n\u003ctd\u003eCrystal Tomato® — distributed and developed in Singapore\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eProduct\u003c\/th\u003e\n\u003ctd\u003eCrystal Tomato® Whitening Supplement (oral pigmentation management)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eActive actives\u003c\/th\u003e\n\u003ctd\u003eStandardised colourless carotenoids: phytoene and phytofluene from proprietary non-GMO tomato cultivar\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eDosage form\u003c\/th\u003e\n\u003ctd\u003eOral tablet, once-daily dosing\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003ePack size\u003c\/th\u003e\n\u003ctd\u003e30 tablets (one-month supply)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eSuggested course\u003c\/th\u003e\n\u003ctd\u003eDermatologist-supervised; clinical evidence is based on 54-day continuous use\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eDietary attributes\u003c\/th\u003e\n\u003ctd\u003eNon-GMO source material; manufacturer states absence of artificial colourants and added hydroquinone\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eManufacturing standards\u003c\/th\u003e\n\u003ctd\u003eManufactured under cGMP; raw material supplied under exclusive arrangement (Lucas Meyer Cosmetics enhanced colourless carotenoid platform, 2024)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eClinical evidence\u003c\/th\u003e\n\u003ctd\u003eDouble-blind, randomised, placebo-controlled clinical trial conducted at the National Skin Centre, Singapore; published in the U.S. Journal of Pigmentary Disorders.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eKey endpoints\u003c\/th\u003e\n\u003ctd\u003e−46% mMASI in active arm vs −35% placebo at day 54; up to 8.9× greater reduction in erythema score; no significant adverse events reported.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003eRegulatory positioning\u003c\/th\u003e\n\u003ctd\u003eHealth Sciences Authority (HSA) Singapore: classified as a health supplement under the Health Products Act, not a registered therapeutic product or medical device. Not intended to diagnose, treat, cure, or prevent any disease.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eKey Applications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAdjunctive oral therapy in dermatologist-managed melasma and post-inflammatory hyperpigmentation, alongside topical agents such as hydroquinone, azelaic acid and tranexamic acid.\u003c\/li\u003e\n\u003cli\u003eMaintenance phase support after laser, intense pulsed light (IPL) or chemical peel pigmentation procedures, where reactivation of melanogenesis is a known risk.\u003c\/li\u003e\n\u003cli\u003eTonal evening and reduction of solar lentigines as part of a structured photoprotection programme in adults with Fitzpatrick III–V phototypes.\u003c\/li\u003e\n\u003cli\u003ePatients seeking a non-prescription oral adjunct to broad-spectrum SPF 50+ sunscreen and physical photoprotection.\u003c\/li\u003e\n\u003cli\u003eLong-haul travellers and outdoor professionals with cumulative UV exposure.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eWhat is the clinical evidence supporting Crystal Tomato® Whitening Supplement?\u003c\/strong\u003e\u003cbr\u003eThe product was evaluated in a double-blind, placebo-controlled, randomised clinical trial conducted at the National Skin Centre, Singapore. The active arm achieved a 46% reduction in modified MASI (mMASI) versus 35% on placebo, with up to 8.9-fold greater improvement in erythema (redness) at 54 days. The study was published in the U.S. Journal of Pigmentary Disorders. Patients should still apply broad-spectrum sunscreen daily; oral supplementation is adjunctive, not substitutive.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAre colourless carotenoids the same as \"white tomato\" extract?\u003c\/strong\u003e\u003cbr\u003eNo. The active phytoene and phytofluene fraction is derived from a proprietary non-GMO red tomato cultivar selectively bred for high colourless-carotenoid yield. The product does not contain hydroquinone, glutathione injectables or skin-bleaching pharmaceuticals.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIs Crystal Tomato® registered with HSA in Singapore?\u003c\/strong\u003e\u003cbr\u003eThe product is supplied as a health supplement under Singapore's Health Products Act regime administered by the Health Sciences Authority (HSA). It is not a registered therapeutic product or medical device. Patients with diagnosed melasma, drug-induced hyperpigmentation or post-inflammatory hyperpigmentation should be evaluated by a dermatologist; supplementation is intended as adjunct to medical management.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIs it safe in pregnancy or with prescription medication?\u003c\/strong\u003e\u003cbr\u003eUse during pregnancy or lactation is not recommended without prior medical advice given the absence of dedicated safety studies in those populations. Patients on retinoid therapy, photosensitising medications (e.g., tetracyclines, amiodarone) or with known carotenoid hypersensitivity should consult their treating physician before initiation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow long before results are visible?\u003c\/strong\u003e\u003cbr\u003ePublished clinical data show measurable mMASI reduction at 54 days. In aesthetic-medicine practice a minimum 8–12 week course is typically recommended, supported by daily SPF 50+ sunscreen and topical depigmenting therapy as prescribed.\u003c\/p\u003e\n\u003ch2\u003eWhy Buy From EMIS+\u003c\/h2\u003e\n\u003cp\u003eEMIS+ (\u003ca href=\"https:\/\/emis.asia\"\u003eemis.asia\u003c\/a\u003e) is a Singapore nurse-led medical supply store. We focus on genuine, quality products, clear guidance, and reliable islandwide delivery for patients, caregivers, and healthcare professionals.\u003c\/p\u003e\n\u003ch2\u003eOrdering \u0026amp; Delivery FAQ\u003c\/h2\u003e\n\u003ch3\u003eWhere can I buy Crystal Tomato Whitening Supplements: Clinically Proven Skin Brightening for Radiant, Luminous Skin in Singapore?\u003c\/h3\u003e\n\u003cp\u003eYou can order Crystal Tomato Whitening Supplements: Clinically Proven Skin Brightening for Radiant, Luminous Skin online from EMIS+ at emis.asia, a Singapore nurse-led medical supply store offering fast islandwide delivery.\u003c\/p\u003e\n\u003ch3\u003eHow quickly will my EMIS+ order be delivered?\u003c\/h3\u003e\n\u003cp\u003eEMIS+ dispatches orders across Singapore, with standard delivery typically arriving within a few working days. Order tracking is provided once your order ships.\u003c\/p\u003e\n\u003ch3\u003eCan I get advice before ordering from EMIS+?\u003c\/h3\u003e\n\u003cp\u003eYes. EMIS+ is a nurse-led store and our team can help with product selection. For medical advice specific to your condition or treatment, please consult your doctor or pharmacist.\u003c\/p\u003e\n\u003ch3\u003eIs this supplement safe for me to take?\u003c\/h3\u003e\n\u003cp\u003eDietary supplements are not a substitute for a balanced diet or medical treatment. Always consult your doctor or pharmacist before starting any new supplement, especially if you are pregnant, breastfeeding, on medication, or managing a health condition.\u003c\/p\u003e\n\u003cdiv style=\"background:#f0f7ff;border-left:4px solid #0057a8;padding:16px;margin-top:20px;\"\u003e\n\u003cstrong\u003eShop with EMIS+:\u003c\/strong\u003e Browse our full range of medical supplies at \u003ca href=\"https:\/\/emis.asia\"\u003eemis.asia\u003c\/a\u003e — Singapore's nurse-led medical supply store.\u003c\/div\u003e\n\u003cscript type=\"application\/ld+json\"\u003e{\"@context\": \"https:\/\/schema.org\", \"@type\": \"FAQPage\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"Where can I buy Crystal Tomato Whitening Supplements: Clinically Proven Skin Brightening for Radiant, Luminous Skin in Singapore?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"You can order Crystal Tomato Whitening Supplements: Clinically Proven Skin Brightening for Radiant, Luminous Skin online from EMIS+ at emis.asia, a Singapore nurse-led medical supply store offering fast islandwide delivery.\"}}, {\"@type\": \"Question\", \"name\": \"How quickly will my EMIS+ order be delivered?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"EMIS+ dispatches orders across Singapore, with standard delivery typically arriving within a few working days. Order tracking is provided once your order ships.\"}}, {\"@type\": \"Question\", \"name\": \"Can I get advice before ordering from EMIS+?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Yes. EMIS+ is a nurse-led store and our team can help with product selection. For medical advice specific to your condition or treatment, please consult your doctor or pharmacist.\"}}, {\"@type\": \"Question\", \"name\": \"Is this supplement safe for me to take?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Dietary supplements are not a substitute for a balanced diet or medical treatment. Always consult your doctor or pharmacist before starting any new supplement, especially if you are pregnant, breastfeeding, on medication, or managing a health condition.\"}}]}\u003c\/script\u003e","brand":"Crystal Tomato","offers":[{"title":"Default Title","offer_id":42668523716686,"sku":null,"price":178.0,"currency_code":"SGD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0613\/3763\/2846\/files\/47_adb3d211-d7a8-45ea-a27e-6cdc320dd230.png?v=1780451976","url":"https:\/\/tw.emis.asia\/products\/crystal-tomato-whitening-supplements-clinically-proven-skin-brightening-for-radiant-luminous-skin","provider":"EMIS+","version":"1.0","type":"link"}